Maiti B R
Acta Physiol Pol. 1982 May-Jun;33(3):139-42.
Effect of prolonged treatment of norethisterone (a progestogen-only contraceptive) was evaluated on adrenomedullary activity in albino rat. Administration of this synthetic steroidal contraceptive in a dosage of 0.5 mg/rat/day, consecutively for 75 days, raised the epinephrine level of the adrenal gland. No other perceptible change was marked in the medullary histology, mitotic incidence or in the norepinephrine level of the adrenal gland after the treatment. It is concluded that prolonged treatment with an even progestogen-only contraceptive, like norethisterone, causes untoward effect at least on adrenomedullary hormonal activity in the albino rat.
评估了炔诺酮（一种仅含孕激素的避孕药）长期治疗对白化大鼠肾上腺髓质活性的影响。以0.5毫克/大鼠/天的剂量连续75天给予这种合成甾体避孕药，可提高肾上腺的肾上腺素水平。治疗后，肾上腺髓质组织学、有丝分裂发生率或去甲肾上腺素水平均未出现其他明显变化。得出的结论是，像炔诺酮这样仅含孕激素的避孕药长期治疗至少会对白化大鼠的肾上腺髓质激素活性产生不良影响。
