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与对照视力正常大鼠相比,紫外线辐射对盲鼠的促红细胞生成作用。

Erythropoietic effect of ultraviolet radiation in blind rats in comparison with control seeing rats.

作者信息

Danieyko-Osman M, Mietkiewski E

出版信息

Acta Physiol Pol. 1982 May-Jun;33(3):169-77.

PMID:7180519
Abstract

In 40 blinded rats erythropoiesis parameters were determined in four groups of 10 animals each and were compared with similar parameters in seeing control rats. Two group of blind rats received ultraviolet radiation 405-289 nm wavelength; 140 000 erg/sec/cm2 daily for 10 minutes during 2 or 4 weeks. Two other groups served as non-irradiated blind controls. The determined parameters showed the following rise (+) or fall (-) in per cent in relation to the non-irradiated rats: haematocrit (H) +3.6 and 9.3; erythrocyte count (E) +15.1 and 13.2; reticulocyte count (R) +65.5 and 184.1; haemoglobin level (Hb) +6.6 and 13.1; 59Fe incorporation index into erythrocytes (EFe) +27.3 and 30.4, into spleen (SFe) +35.8 and 34.3, into liver (LFe) -20.9 and -19.3, into bone marrow (BFe) -22.8 and -41.9. In the seeing animals all these parameters were significantly greater; H +11.4 and 7.9; E +56.9 and 26.6; R +288.9 and 199.1; Hb +22.3 and 5.1; EFe +64.1 and 42.5; SFe +195.8 and 134.7; LFe -35.4 and -29.9; BFe -65.2 and -57.2.

摘要

在40只致盲大鼠中,将每组10只动物分为四组,测定其红细胞生成参数,并与视觉正常的对照大鼠的相似参数进行比较。两组致盲大鼠接受波长为405 - 289 nm的紫外线辐射;每天140000尔格/秒/平方厘米,持续10分钟,共照射2周或4周。另外两组作为未照射的致盲对照组。所测定的参数相对于未照射大鼠的百分比变化如下:血细胞比容(H)分别升高3.6%和9.3%;红细胞计数(E)分别升高15.1%和13.2%;网织红细胞计数(R)分别升高65.5%和184.1%;血红蛋白水平(Hb)分别升高6.6%和13.1%;红细胞中59Fe掺入指数(EFe)分别升高27.3%和30.4%,脾脏中(SFe)分别升高35.8%和34.3%,肝脏中(LFe)分别降低20.9%和19.3%,骨髓中(BFe)分别降低22.8%和41.9%。在视觉正常的动物中,所有这些参数都显著更高:H分别升高11.4%和7.9%;E分别升高56.9%和26.6%;R分别升高288.9%和199.1%;Hb分别升高22.3%和5.1%;EFe分别升高64.1%和42.5%;SFe分别升高195.8%和134.7%;LFe分别降低35.4%和29.9%;BFe分别降低65.2%和57.2%。

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