Linde B, Rosell S, Rökaeus A
Acta Physiol Scand. 1982 Jul;115(3):311-5. doi: 10.1111/j.1748-1716.1982.tb07083.x.
(Gln4)-neurotensin, 18 pmolXkg-1Xmin-1, was infused i.v. during 20 min in 10 healthy male volunteers. Adipose tissue blood flow was continuously monitored by measuring the disappearance rate of 99mTc-pertechnetate injected s.c. on the abdomen and thigh. Heart rate and blood pressure were measured and calf blood flow studied by venous occlusion plethysmography. Neurotensin-like immunoreactivity (NTLI) in serum was determined. Infusion of isotonic saline served as control. During intravenous infusion of (Gln4)-neurotensin the first order rate constants of 99mTc-pertechnetate from the abdomen decreased by 21.9 +/- 5.9% from a basal value of 8.3 +/- 0.5% min-1 (p less than 0.01). The reduction in blood flow started after a latent period of 5-10 min and persisted throughout the thirty minute observation period following infusion. A significant correlation (r=0.87, p less than 0.001) was found between the percentage decrease in blood flow from abdominal fat and the body fat content of the subjects as determined from the sum of four skinfolds. Blood flow from thigh fat did not change significantly, nor did heart rate, blood pressure or calf blood flow. During infusion of (Gln4)-neurotensin plasma neurotensin-like immunoreactivity (NTLI) increased successively. Ten minutes after starting the infusion the mean plasma NTLI level had increased from 20 +/- 5 pM to 302 +/- 31 pM; at 20 min it was 473 +/- 51 pM. These concentrations are within the range found after eating a fatty meal. The results indicate that neurotensin plays a physiological role in the regulation of human adipose tissue blood flow and may be of importance for the postprandial uptake of substrates in adipose tissue in certain regions. We suggest that neurotensin deserves consideration as an endocrine hormone affecting the regional deposition of fat postprandially.
向10名健康男性志愿者静脉内输注（谷氨酰胺4）-神经降压素，剂量为18 pmol·kg⁻¹·min⁻¹，持续20分钟。通过测量皮下注射在腹部和大腿的⁹⁹ᵐTc-高锝酸盐的消失率来连续监测脂肪组织血流量。测量心率和血压，并通过静脉阻塞体积描记法研究小腿血流量。测定血清中的神经降压素样免疫反应性（NTLI）。输注等渗盐水作为对照。在静脉输注（谷氨酰胺4）-神经降压素期间，腹部⁹⁹ᵐTc-高锝酸盐的一级速率常数从基础值8.3±0.5%·min⁻¹下降了21.9±5.9%（p<0.01）。血流量的减少在5-10分钟的潜伏期后开始，并在输注后的30分钟观察期内持续存在。发现腹部脂肪血流量减少的百分比与根据四处皮褶厚度总和确定的受试者体脂含量之间存在显著相关性（r=0.87，p<0.001）。大腿脂肪的血流量没有显著变化，心率、血压或小腿血流量也没有变化。在输注（谷氨酰胺4）-神经降压素期间，血浆神经降压素样免疫反应性（NTLI）持续增加。输注开始10分钟后，血浆NTLI平均水平从20±5 pM增加到302±31 pM；20分钟时为473±51 pM。这些浓度在进食高脂肪餐后测得的范围内。结果表明，神经降压素在调节人体脂肪组织血流量中起生理作用，并且可能对某些区域脂肪组织餐后底物的摄取很重要。我们建议神经降压素应被视为一种影响餐后脂肪区域沉积的内分泌激素。
