Rosell S, Burcher E, Chang D, Folkers K
Acta Physiol Scand. 1976 Dec;98(4):484-91. doi: 10.1111/j.1748-1716.1976.tb10340.x.
The actions of the tridecapeptides neurotensin and (Gln4)-neurotensin have been studied on the heart and on the blood flow in subcutaneous adipose tissue, skin and small intestine of anesthetized dogs. In addition, their possible actions have been investigated on blood glucose concentration and lipolysis in subcutaneous adipose tissue. The two peptides were found to be approximately equipotent. Intravenous infusion of 20-120 ng X kg-1 X min-1 produced slight hypotension, an initial vasodilatation in the small intestine and a delayed vasoconstriction in denervated subcutaneous adipose tissue and to a lesser extent in the skin and small intestine. At this infusion rate, neurotensin and (Gln4)-neurotensin did not elicit vasodilatation in the skin or adipose tissue and had no effect on heart rate. The delayed vasoconstriction in adipose tissue was not inhibited by local alpha-receptor blockade. Both neurotensin and (Gln4)-neurotensin increased glucose concentration in the upper dose range. No effects on lipolysis were observed, either in vivo or in vitro. These experiments show that neurotensin and (Gln4)-neurotensin have both vasodilator and vasoconstrictor actions in the peripheral vasculature but seem to be without cardiac actions. They also increase blood glucose concentration. It remains to be shown whether these actions are direct or whether some are indirectly mediated.
已对十三肽神经降压素和（谷氨酰胺4）-神经降压素在麻醉犬的心脏以及皮下脂肪组织、皮肤和小肠中的血流方面的作用进行了研究。此外，还研究了它们对皮下脂肪组织中血糖浓度和脂肪分解的可能作用。发现这两种肽的效力大致相当。以20 - 120 ng·kg⁻¹·min⁻¹的速率静脉输注会产生轻微低血压，小肠出现初始血管舒张，去神经支配的皮下脂肪组织出现延迟血管收缩，皮肤和小肠的血管收缩程度较轻。在此输注速率下，神经降压素和（谷氨酰胺4）-神经降压素不会引起皮肤或脂肪组织血管舒张，且对心率无影响。脂肪组织中的延迟血管收缩不受局部α受体阻断的抑制。神经降压素和（谷氨酰胺4）-神经降压素在较高剂量范围内均会增加血糖浓度。在体内或体外均未观察到对脂肪分解的影响。这些实验表明，神经降压素和（谷氨酰胺4）-神经降压素在外周血管系统中既有血管舒张作用又有血管收缩作用，但似乎对心脏无作用。它们还会增加血糖浓度。这些作用是直接的还是部分通过间接介导的，仍有待证实。
