Lundin S, Herlitz H, Hallbäck-Nørdlander M, Ricksten S E, Göthberg G, Berglund G
Acta Physiol Scand. 1982 Jul;115(3):317-23. doi: 10.1111/j.1748-1716.1982.tb07084.x.
Sodium balance was studied in 7 and 16 week old male spontaneously hypertensive rats (SHR), in matched normotensive Wistar rats (NCR) and in Wistar Kyoto rats (WKR). The animals were placed in metabolic cages and given diets with either normal sodium content (5.35 mmol sodium/100 g food) or with a sodium content 3 or 10 times the normal. Whether on normal or increased sodium diet we did not observe any increased sodium retention in either SHR age group. However, in both SHR groups urinary sodium excretion was correspondingly increased compared with the controls. This shift of sodium excretion from kidneys to gastrointestinal tract in SHR did not reflect any 'primary' inability of the SHR kidneys to excrete sufficient sodium amounts since on high sodium diet they excreted the increased sodium load as readily as the normotensive controls. The present results do not support the concept that a primary renal retention of sodium and water should be of pathogenetic importance for the SHR variant of primary hypertension.
对7周龄和16周龄的雄性自发性高血压大鼠（SHR）、配对的正常血压Wistar大鼠（NCR）以及Wistar Kyoto大鼠（WKR）的钠平衡进行了研究。将动物置于代谢笼中，并给予正常钠含量（5.35 mmol钠/100 g食物）或钠含量为正常3倍或10倍的饮食。无论给予正常钠饮食还是高钠饮食，我们在两个SHR年龄组中均未观察到任何钠潴留增加的情况。然而，与对照组相比，两个SHR组的尿钠排泄相应增加。SHR中钠排泄从肾脏向胃肠道的这种转变并不反映SHR肾脏存在任何“原发性”排泄足够量钠的能力不足，因为在高钠饮食时，它们与正常血压对照组一样容易排泄增加的钠负荷。目前的结果不支持原发性肾钠和水潴留对原发性高血压的SHR变异型具有致病重要性这一概念。
