Haug J O
Acta Psychiatr Scand. 1982 Nov;66(5):374-83. doi: 10.1111/j.1600-0447.1982.tb06719.x.
Pneumoencephalography (PEG) was carried out in 50 patients of both sexes consecutively discharged from a psychiatric department with a diagnosis of acute schizophrenia. At clinical follow-up with a mean observation time of 8 years the diagnosis was verified in 38 patients, while 12 were considered to have had a reactive psychosis. The PEG findings and clinical findings in these two groups are compared, and compared to corresponding findings in 101 chronic schizophrenics previously studied with the same method. Linear measurements were used in estimating the size of the ventricular system, which was safely within normal limits in all but three of the 50 patients. Mean ventricular size did not differ significantly in the two groups of acute psychoses. No case of cortical atrophy was found. More than half of the chronic schizophrenics had abnormal PEG's, the typical finding being a bilateral enlargement of the ventricular system. The mean size of all parts of the ventricular system was significantly higher than in the acute schizophrenics. A close correlation was found between mental deterioration and ventricular enlargement. The most reasonable explanation of these findings is that schizophrenia is an inborn error of metabolism, disturbing normal brain function and in the long run leading to degenerative changes of the nervous tissue.
对50例男女患者进行了气脑造影（PEG），这些患者均为从精神科连续出院、诊断为急性精神分裂症的患者。在平均观察时间为8年的临床随访中，38例患者的诊断得到证实，而12例被认为患有反应性精神病。比较了这两组患者的PEG检查结果和临床检查结果，并与之前用相同方法研究的101例慢性精神分裂症患者的相应检查结果进行了比较。采用线性测量来估计脑室系统的大小，50例患者中除3例之外，其余患者的脑室大小均在正常范围内。两组急性精神病患者的平均脑室大小无显著差异。未发现皮质萎缩病例。超过半数的慢性精神分裂症患者气脑造影结果异常，典型表现为脑室系统双侧扩大。脑室系统各部分的平均大小显著高于急性精神病患者。发现精神衰退与脑室扩大之间存在密切相关性。对这些研究结果最合理的解释是，精神分裂症是一种先天性代谢缺陷，扰乱了正常的脑功能，并最终导致神经组织的退行性变化。
