Blood pressure, cardiac output and systemic vascular resistance during rest, muscle work, cold pressure test and psychological stress. A study of male offspring from families with a history of essential hypertension for at least two generations.

Haemodynamic changes in the early phases of hypertensive diseases have mainly been described in so-called borderline hypertensives. Their cardiac output (CO) has mostly been found to be elevated, but the peripheral vascular resistance (PRI) normal. In this study of the offspring (26 subjects) of hypertensive individuals, CO and intravascular pressures were measured during rest, muscular work, psychological stress and cold pressure test. For comparison, the same measurements were performed in a control group of healthy volunteers without known hypertension in their families. The offspring had higher blood pressure at rest than the controls throughout the study except during the cold pressure test and the highest dynamic work loads. Although there was no statistically significant difference between offspring and controls as regards PRI, the resistance was slightly higher in the group of offspring throughout the study. Arterial blood pCO2 in offspring was significantly lower at rest, during psychological stress and dynamic muscle work. Possible mechanisms behind this finding are considered.