Ekström L G, Slanina P
Acta Vet Scand. 1982;23(3):313-24. doi: 10.1186/BF03546783.
A specific Polarographic method with a sensitivity of ≥ 2 jig/kg (ppb) has been used to determine the plasma and tissue concentrations of nitroxynil (NTX), which is used against Parafilaria bovicola in cattle. After treatment with the therapeutic dose on NTX (2 × 20 mg/kg b.w., s,c), there was an initial rapid decrease in the plasma concentration followed by a slower elimination phase. The plasma levels of NTX were 8 mg/kg (ppm) and 3 mg/kg after 6 weeks and 2 months, respectively. The muscle and other edible tissue from treated cattle contained 0.1–0.3 mg/kg NTX after 2 months, and jxg/kg amounts were still detectable 3 months after the injection. Based on available pharmacological and toxicological data, a 3-months withdrawal time for NTX in cattle is proposed.
一种灵敏度≥2微克/千克（ppb）的特定极谱法已被用于测定硝羟碘苄腈（NTX）在血浆和组织中的浓度，硝羟碘苄腈用于治疗牛的副丝虫病。用治疗剂量的NTX（2×20毫克/千克体重，皮下注射）治疗后，血浆浓度最初迅速下降，随后是较慢的消除阶段。NTX的血浆水平在6周和2个月后分别为8毫克/千克（ppm）和3毫克/千克。治疗后2个月，处理过的牛的肌肉和其他可食用组织中含有0.1 - 0.3毫克/千克的NTX，注射后3个月仍可检测到微克/千克的含量。根据现有的药理和毒理学数据，建议牛的NTX停药期为3个月。
