Kwapinski G, Kwapinski E H
Allergol Immunopathol (Madr). 1982 Jul-Aug;10(4):301-4.
Repeated injections of microbial polysaccharide-nucleoproteins into mice elicited progressive hyperplasia of the reticuloendothelial system and fulminating proliferation of undifferentiated cells in the spleen, lymph nodes and liver, displaying the pathology of acute leukemia and resulting in the death of afflicted animals within a few months. It is postulated that long-lasting exposures to microbial antigens of the individuals genetically predisposed to leukemia may present a mechanism for its pathogenesis.
向小鼠反复注射微生物多糖 - 核蛋白会引发网状内皮系统的进行性增生以及脾脏、淋巴结和肝脏中未分化细胞的暴发性增殖，呈现出急性白血病的病理特征，并导致患病动物在几个月内死亡。据推测，对于具有白血病遗传易感性的个体，长期接触微生物抗原可能是其发病机制。
