Pfenninger J, Sutter M
Anaesthesia. 1982 Dec;37(12):1157-62. doi: 10.1111/j.1365-2044.1982.tb01779.x.
Six children who remained in deep coma after immersion accidents in fresh water received therapy to maintain normal intracranial pressure (ICP). This involved controlled ventilation to ensure hypocapnia and hyperoxaemia, maintenance of low normothermia, fluid restriction, dexamethasone (1-1.5 mg/kg initially, 1-1.5 mg/kg/day as maintenance) and barbiturates (phenobarbitone and thiopentone). The latter were given in a wide range of dosage. Increased ICP was common to all patients, but could always be kept at acceptable levels. All patients suffered from pulmonary oedema; three developed broncho-pneumonia and two developed adult respiratory distress syndrome. All children survived with good recovery, two needed active rehabilitation for several months.
六名在淡水溺水事故后仍处于深度昏迷状态的儿童接受了维持正常颅内压(ICP)的治疗。这包括控制性通气以确保低碳酸血症和高氧血症、维持轻度低温、限制液体摄入、使用地塞米松(初始剂量为1 - 1.5毫克/千克,维持剂量为1 - 1.5毫克/千克/天)和巴比妥类药物(苯巴比妥和硫喷妥钠)。后者的给药剂量范围很广。所有患者均出现颅内压升高,但总能保持在可接受水平。所有患者都患有肺水肿;三名患者发展为支气管肺炎,两名患者发展为成人呼吸窘迫综合征。所有儿童均存活且恢复良好,两名儿童需要进行数月的积极康复治疗。