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1
Prenatal exclusion of severe combined immunodeficiency.产前排除重症联合免疫缺陷。
Arch Dis Child. 1982 Dec;57(12):958-60. doi: 10.1136/adc.57.12.958.
2
Prenatal diagnosis of severe combined immunodeficiency.
J Pediatr. 1982 Dec;101(6):995-7. doi: 10.1016/s0022-3476(82)80029-2.
3
A monoclonal antibody micromethod for studying fetal lymphocytes: potential for prenatal diagnosis of inherited immunodeficiencies.一种用于研究胎儿淋巴细胞的单克隆抗体微量方法：遗传性免疫缺陷产前诊断的潜力
J Reprod Immunol. 1984 Dec;6(6):341-4. doi: 10.1016/0165-0378(84)90043-3.
4
Prenatal diagnosis of immunodeficiency diseases.免疫缺陷疾病的产前诊断
Curr Probl Dermatol. 1987;16:185-96. doi: 10.1159/000413465.
5
Prenatal testing for inherited immune deficiencies by fetal blood sampling.通过胎儿血液采样进行遗传性免疫缺陷的产前检测。
Prenat Diagn. 1982 Apr;2(2):109-13. doi: 10.1002/pd.1970020206.
6
Antenatal diagnosis of severe combined immunodeficiency from fetal cord blood.通过胎儿脐带血进行严重联合免疫缺陷的产前诊断。
Lancet. 1982 Apr 10;1(8276):852-3. doi: 10.1016/s0140-6736(82)91898-0.
7
Prenatal test for X-linked severe combined immunodeficiency by analysis of maternal X-chromosome inactivation and linkage analysis.
N Engl J Med. 1990 Apr 12;322(15):1063-6. doi: 10.1056/NEJM199004123221508.
8
Prenatal diagnosis of severe combined immunodeficiency with defective synthesis of HLA molecules.伴有HLA分子合成缺陷的严重联合免疫缺陷的产前诊断。
Prenat Diagn. 1987;7(1):27-34. doi: 10.1002/pd.1970070106.
9
Prenatal diagnosis for severe combined immunodeficiency.严重联合免疫缺陷的产前诊断
Birth Defects Orig Artic Ser. 1983;19(3):121-3.
10
Prenatal diagnosis and carrier detection in primary immunodeficiency disorders.原发性免疫缺陷病的产前诊断与携带者检测
Arch Dis Child. 1988 Jul;63(7 Spec No):758-64. doi: 10.1136/adc.63.7_spec_no.758.

引用本文的文献

1
Prenatal diagnosis of three cases of severe combined immunodeficiency: severe T cell deficiency during the first half of gestation in fetuses with adenosine deaminase deficiency.三例重症联合免疫缺陷的产前诊断：腺苷脱氨酶缺乏胎儿在妊娠前半期严重T细胞缺乏。
Clin Exp Immunol. 1984 May;56(2):223-32.
2
Development of lymphocyte subpopulations identified by monoclonal antibodies in human fetuses.通过单克隆抗体鉴定的人胎儿淋巴细胞亚群的发育
J Clin Immunol. 1984 Jan;4(1):36-9. doi: 10.1007/BF00915285.
3
Prenatal exclusion of purine nucleoside phosphorylase deficiency.
Eur J Pediatr. 1986 Apr;145(1-2):51-3. doi: 10.1007/BF00441852.
4
Suppressor-cell dysfunction in children with histiocytosis-X.组织细胞增多症-X患儿的抑制细胞功能障碍。
J Clin Immunol. 1986 Nov;6(6):510-8. doi: 10.1007/BF00915257.

本文引用的文献

1
A monoclonal antibody reactive with human peripheral blood monocytes.一种与人外周血单核细胞反应的单克隆抗体。
J Immunol. 1980 Apr;124(4):1943-8.
2
Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen.人类中依赖胸腺的膜抗原：抗TH2抗原单克隆抗体对细胞介导的淋巴细胞溶解的抑制作用
Proc Natl Acad Sci U S A. 1981 Jan;78(1):544-8. doi: 10.1073/pnas.78.1.544.
3
Phenotypic analysis of fetal blood leucocytes: potential for prenatal diagnosis of immunodeficiency disorders.胎儿血白细胞的表型分析：免疫缺陷疾病产前诊断的潜力
Prenat Diagn. 1982 Jul;2(3):211-8. doi: 10.1002/pd.1970020310.
4
Antenatal diagnosis of severe combined immunodeficiency from fetal cord blood.通过胎儿脐带血进行严重联合免疫缺陷的产前诊断。
Lancet. 1982 Apr 10;1(8276):852-3. doi: 10.1016/s0140-6736(82)91898-0.
5
Monoclonal antibodies for analysis of the HLA system.用于分析人类白细胞抗原（HLA）系统的单克隆抗体。
Immunol Rev. 1979;47:3-61. doi: 10.1111/j.1600-065x.1979.tb00288.x.

产前排除重症联合免疫缺陷。

Prenatal exclusion of severe combined immunodeficiency.

作者信息

Levinsky R J, Linch D C, Beverly C L, Rodeck C

出版信息

Arch Dis Child. 1982 Dec;57(12):958-60. doi: 10.1136/adc.57.12.958.

DOI:10.1136/adc.57.12.958
PMID:7181530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1628064/
Abstract

By analysing leucocyte subpopulations with monoclonal antisera, we have shown that the diagnosis of severe combined immunodeficiency can be made soon after birth. The technique of staining has been adapted for small blood samples, and normal ranges of leucocyte subpopulations have been established for fetal blood taken from mid-trimester pregnancies. Using this information, we gave prenatal advice to an at risk family and predicted that the pregnancy would be normal; this was confirmed after birth. This technique should allow prenatal diagnosis for severe combined immunodeficiency, especially if the phenotype of a previously affected child is known.

摘要

通过用单克隆抗血清分析白细胞亚群，我们已经表明，严重联合免疫缺陷的诊断在出生后不久即可做出。染色技术已适用于少量血液样本，并且已经确定了孕中期妊娠胎儿血液中白细胞亚群的正常范围。利用这些信息，我们向一个有风险的家庭提供了产前建议，并预测该妊娠将是正常的；出生后得到了证实。这项技术应能实现严重联合免疫缺陷的产前诊断，特别是如果已知先前患病儿童的表型。