X-537A（拉沙洛西）对大鼠心室肌钾挛缩的影响。

The effect of X-537A (lasalocid) on potassium contracture in rat ventricular muscle.

作者信息

Lehr J T, Gaide M S, Ezrin A M, Wiggins J, Bassett A L

出版信息

Arch Int Pharmacodyn Ther. 1982 Sep;259(1):106-11.

Abstract

The effects of the carboxylic ionophore X-537A on contracture induced by high external K+ were determined in stimulated and unstimulated rat papillary muscles. X-537A (5 X 10(-6) M - 10(-5) M) increased peak K+-contracture force in stimulated but not unstimulated muscle. X-537A may alter myocardial force development by influencing transport of Ca2+ across the sarcolemma or Ca2+ release from sarcoplasmic reticulum.

摘要

在受刺激和未受刺激的大鼠乳头肌中，测定了羧酸离子载体X - 537A对高细胞外钾诱导的挛缩的影响。X - 537A（5×10⁻⁶M - 10⁻⁵M）增加了受刺激肌肉的钾挛缩峰值力，但未增加未受刺激肌肉的钾挛缩峰值力。X - 537A可能通过影响钙离子跨肌膜的转运或肌浆网中钙离子的释放来改变心肌力的产生。