Newhouse M, McEvoy D, Rosenthal D
Arch Dermatol. 1978 Oct;114(10):1516-9. doi: 10.1001/archderm.114.10.1516.
Striking cutaneous lesions and death owing to respiratory failure occurred in a middle-aged woman eight weeks after initial cutaneous contact with the herbicide paraquat (1,1'dimethyl-4,4'dipyridylium dichloride). While similar changes have been described in animals, to our knowledge, serious morbidity or mortality owing to percutaneous absorption has not been described in man. This case report illustrates the extreme toxicity of this herbicide and demonstrates that lethal quantities of the drug may be absorbed from apparently trivial skin wounds. Stricter precautions, including the mandatory use of protective clothing, should be recommended whenever this material is used.
一名中年女性在最初皮肤接触除草剂百草枯（1,1'-二甲基-4,4'-联吡啶二氯化物）八周后，出现了明显的皮肤损伤并因呼吸衰竭死亡。虽然在动物身上已描述过类似变化，但据我们所知，人类经皮吸收导致的严重发病或死亡情况尚未见报道。本病例报告说明了这种除草剂的极端毒性，并表明该药物的致死量可能会从看似轻微的皮肤伤口吸收。每当使用这种物质时，都应建议采取更严格的预防措施，包括强制使用防护服。
