Mathe G, Gouveia J, Hercend T, Gros F, Dorval T, Hazon J, Misset J L, Schwarzenberg L, Ribaud P, Lemaigre G, Santelli G, Reizenstein P, Homasson J P, Gaillard J P, Angebault M, Bonniot J P, Lededente A, Marsac J, Parrot R, Pretet S, Gaget H
Cancer Detect Prev. 1982;5(4):461-6.
Vitamin A and its derivatives, so-called retinoids, can prevent squamous metaplasia induced not only by vitamin A deficiency but also by carcinogenic hydrocarbons. An aromatic retinoid, such as ET1, has been shown to prevent chemically induced papillomas in mice and to amplify certain immunologic reactions. Heavy smokers, 106 volunteers, were submitted to fibrobronchoscopy with bronchial biopsies. An index of metaplasia (IM) was calculated on the basis of microscopical examination of a total of 9,633 sections of 1,010 biopsies. Despite the subjectivity of the estimates of cigarette consumption, this was significantly (P less than 0.02) and positively correlated to the IM. Eighty-five percent of the women had a low IM as compared to only 42% of the men (P less than 0.01), although there was no significant difference in the reported cigarette consumption. Fifty-two subjects had an IM greater than 15% and were given 25 mg ET1 orally daily for 6 months. The bronchoscopy was repeated in 30 patients following completion of the 6-month treatment. The IM was significantly (P less than 0.01) reduced after treatment.
维生素A及其衍生物，即所谓的类视黄醇，不仅可以预防由维生素A缺乏引起的鳞状化生，还能预防由致癌碳氢化合物导致的鳞状化生。一种芳香族类视黄醇，如ET1，已被证明可以预防小鼠化学诱导的乳头状瘤，并增强某些免疫反应。106名重度吸烟者接受了纤维支气管镜检查并进行了支气管活检。根据对1010份活检标本共9633个切片的显微镜检查计算化生指数（IM）。尽管对香烟消费量的估计存在主观性，但它与IM显著正相关（P<0.02）。85%的女性IM较低，而男性只有42%（P<0.01），尽管报告的香烟消费量没有显著差异。52名受试者的IM大于15%，他们每天口服25毫克ET1，持续6个月。6个月治疗结束后，30名患者再次接受支气管镜检查。治疗后IM显著降低（P<0.01）。
