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[新生儿促甲状腺激素放射免疫测定中不同质量滤纸的方法学研究]

[Methodological study of different qualities of filter paper in the radioimmunological determination of thyrotropin in newborn infants].

作者信息

Höpfner B

出版信息

J Clin Chem Clin Biochem. 1982 Dec;20(12):915-20.

PMID:7182429
Abstract

In the screening of newborns for congenital hypothyroidism, filter paper cards act as sample carriers for capillary blood specimens, and for reference quantities of the measured hormones. Therefore, the quality of the filter paper is especially important and must be taken into account. Different types of filter paper and different guide marks on the paper surface for spotting blood specimens were investigated. The hormone distribution within the dried blood spot and the time necessary to extract the hormones were examined in relation to the sensitivity and yield of the test kit.

摘要

在新生儿先天性甲状腺功能减退症筛查中,滤纸卡片用作毛细血管血标本以及所测激素参考量的样本载体。因此,滤纸的质量尤为重要,必须予以考虑。研究了不同类型的滤纸以及纸表面用于血标本点样的不同引导标记。针对检测试剂盒的灵敏度和产量,考察了干血斑内激素的分布情况以及提取激素所需的时间。

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