苦杏仁苷的代谢产物野黑樱苷的药代动力学。
The pharmacokinetics of prunasin, a metabolite of amygdalin.
作者信息
Rauws A G, Olling M, Timmerman A
出版信息
J Toxicol Clin Toxicol. 1982 Oct;19(8):851-6. doi: 10.3109/15563658208992518.
PMID:7182513
Abstract
The pharmacokinetics of prunasin have been investigated in the dog. The results are compared with results obtained with amygdalin. The volume of distribution and the clearance of prunasin are larger than those of amygdalin. The oral bioavailability of prunasin is approximately 50%, whereas amygdalin is hardly absorbed unchanged.
摘要
已对苦杏仁苷在犬体内的药代动力学进行了研究。将结果与苦杏仁甙的研究结果进行了比较。苦杏仁苷的分布容积和清除率均大于苦杏仁甙。苦杏仁苷的口服生物利用度约为50%，而苦杏仁甙几乎不被原样吸收。
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