Bültmann B, Melzner I, Haferkamp O, Gruler H
Pathol Res Pract. 1982;175(2-3):308-11. doi: 10.1016/S0344-0338(82)80117-9.
By means of the excimer-forming lipid technique changes of membrane fluidity of human PMNs exposed to a chemoattractant (FMLP) and/or Echo virus, type 9, strain A. Barty has been investigated. It was shown that preincubation of PMNs with Echo 9 virus results in a viral dose-dependent decrease of membrane fluidity of granulocytes exposed to FMLP. The virus-induced rigidity of cell membrane causes obviously a disturbance in the aggregation of membrane particles to form receptors, and thus can lead to a failure of regular processing of chemotactic signals.
通过准分子形成脂质技术，研究了暴露于趋化因子（FMLP）和/或9型埃可病毒A株的人中性粒细胞的膜流动性变化。结果表明，用埃可9型病毒预孵育中性粒细胞会导致暴露于FMLP的粒细胞膜流动性呈病毒剂量依赖性降低。病毒诱导的细胞膜刚性明显导致膜颗粒聚集形成受体的过程受到干扰，从而可能导致趋化信号的正常处理失败。
