钙介导的电压依赖性钾电流降低。
Calcium-mediated decrease of a voltage-dependent potassium current.
作者信息
Alkon D L, Shoukimas J J, Heldman E
出版信息
Biophys J. 1982 Dec;40(3):245-50. doi: 10.1016/S0006-3495(82)84479-2.
Abstract
Elevated intracellular Ca++ concentration reduces the amplitude of an early, voltage-dependent K+ current (IA) in the Type B photoreceptor of Hermissenda crassicornis. Internal Ca++ is increased by activating a voltage and light-dependent Ca++ current present in these cells or by direct iontophoresis of Ca++ ions. Substitution of Ba++ for Ca++ or elimination of Ca++ from the sea water bathing the cells abolishes the reduction in IA during paired light and depolarizing voltage steps. The delayed K+ current (IB) in these cells is also reduced during paired light and voltage steps, but this decrease of IB is not affected by removal of extracellular Ca++. IB (but not IA), apparently much less dependent on intracellular Ca++ levels, is reduced by light alone. Ca++ iontophoresis also abolishes the light-dependent Na+ current, which recovers with a time course of minutes.
摘要
细胞内钙离子浓度升高会降低肥大海兔B型光感受器中早期电压依赖性钾电流（IA）的幅度。通过激活这些细胞中存在的电压和光依赖性钙电流或通过钙离子的直接离子电渗法可增加细胞内钙离子。用钡离子替代钙离子或从浸泡细胞的海水中去除钙离子，可消除在配对光和去极化电压阶跃期间IA的降低。在配对光和电压阶跃期间，这些细胞中的延迟钾电流（IB）也会降低，但IB的这种降低不受细胞外钙离子去除的影响。显然对细胞内钙离子水平依赖性小得多的IB（而非IA），仅受光的影响而降低。钙离子电渗法也会消除光依赖性钠电流，该电流会在数分钟的时间进程内恢复。
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