Menahan L A
Exp Gerontol. 1982;17(6):453-61. doi: 10.1016/s0531-5565(82)80007-7.
The consequence of aging on carbohydrate and lipid metabolism of the Swiss albino mouse was examined in a complete aging profile. The profile was developed by obtaining groups of at least 10 weanling mice at 2-3 month intervals for approximately a 2-year period. Body weight plateaued at approximately 10 months-of-age. Maximal heart and liver weights were found in 3-month-old mice. Plasma glucose concentration was highest in 1-month-old mice, declined rapidly during the first 3 months-of-age and then gradually throughout the profile. Liver glycogen content spiked sharply in 2-month-old mice, decreasing sharply to a level maintained in mature animals. A second peak in hepatic glycogen occurred in 15-month-old mice with a precipitous decrease taking place in older animals. Plasma concentrations of glycerol, 3-hydroxybutyrate and triacylglycerols, indices of lipid metabolism, were remarkably constant and showed no consistent trend with age. The level of triacylglycerols in the heart peaked in 2-month-old mice and then decreased gradually in older animals. The maximal content of triacylglycerols in the liver was found in 10- to 20-month-old mice. Hepatic levels of triacylglycerols decreased precipitously in senescent Swiss albino mice.
在一个完整的衰老过程中，研究了衰老对瑞士白化小鼠碳水化合物和脂质代谢的影响。该过程通过每隔2 - 3个月获取至少10组断奶小鼠，持续约2年时间来建立。体重在约10月龄时趋于平稳。3月龄小鼠的心脏和肝脏重量最大。血浆葡萄糖浓度在1月龄小鼠中最高，在最初3个月龄期间迅速下降，然后在整个过程中逐渐下降。肝脏糖原含量在2月龄小鼠中急剧上升，随后急剧下降至成熟动物维持的水平。肝脏糖原在15月龄小鼠中出现第二个峰值，在老年动物中急剧下降。甘油、3 - 羟基丁酸和三酰甘油的血浆浓度作为脂质代谢指标，相当稳定，且未显示出与年龄一致的趋势。心脏中三酰甘油水平在2月龄小鼠中达到峰值，然后在老年动物中逐渐下降。肝脏中三酰甘油的最大含量在10至20月龄小鼠中发现。衰老的瑞士白化小鼠肝脏中三酰甘油水平急剧下降。
