Elamin E A, Homeida A M, Adam S E, Mahmoud M M
J Vet Pharmacol Ther. 1982 Dec;5(4):259-65. doi: 10.1111/j.1365-2885.1982.tb00441.x.
The efficacy of berenil (diminazene aceturate) was studied in experimental Trypanosoma evansi infection in albino mice. The criteria used for the assessment of the anti-trypanosomal effect of berenil included the examination of the blood and tissues for T. evansi and the clinical, pathological and enzyme histochemical changes seen in the lungs, heart, liver, kidney and spleen at intervals after treatment. Single doses of 10 and 20 mg/kg of berenil given intraperitoneally or intramuscularly to infected mice produced a complete elimination of the protozoon and caused a slow tissue recovery mirrored in the persistence of lesions in different organs. Single doses of 3.5 mg/kg of berenil were less effective and none of the three dose levels of the drug used induced toxic effects in albino mice.
研究了贝尼尔（乙酰甘氨酸二脒那嗪）对白化病小鼠实验性伊氏锥虫感染的疗效。评估贝尼尔抗锥虫作用的标准包括检查血液和组织中的伊氏锥虫，以及在治疗后的不同时间间隔观察肺、心脏、肝脏、肾脏和脾脏的临床、病理和酶组织化学变化。给感染小鼠腹腔内或肌肉内注射单剂量10毫克/千克和20毫克/千克的贝尼尔，可使原虫完全清除，并导致组织缓慢恢复，不同器官的病变持续存在。单剂量3.5毫克/千克的贝尼尔效果较差，所用的三个剂量水平的药物均未对白化病小鼠产生毒性作用。
