Loctin J, Delost P
Steroids. 1982 Sep;40(3):319-29. doi: 10.1016/0039-128x(82)90043-5.
The concentrations of aldosterone in the plasma and adrenal glands, the concentrations of sodium and potassium in the plasma and the hematocrit were estimated from birth to day 6 after birth in premature mice removed by Caesarean section on day 19 of pregnancy in comparison with newborn mice delivered spontaneously vaginally on day 20 of pregnancy. In premature mice, the plasma aldosterone concentrations increased twice: at birth after reanimation, then at 6 h after birth. The first increase at birth resulted probably from ACTH stimulation. Several factors could be involved in the peak at 6 h after birth: ACTH stimulation, the decrease in the level of sodium in the plasma and the increase in the hematocrit due to kidney immaturity of premature mice. The results suggest that the renin-angiotensin-aldosterone system is able to respond to stimulations in the first 6 h after birth in premature mice. The rise in the level of plasma aldosterone which has been found at birth in newborns delivered spontaneously vaginally on day 20 of pregnancy (control animals) did not result from variations of plasma electrolytes, plasma volume and ACTH; this rise has been induced by labor of the parturition which caused the aldosterone release from adrenal glands.
对妊娠第19天通过剖腹产取出的早产小鼠，从出生到出生后第6天，评估其血浆和肾上腺中醛固酮的浓度、血浆中钠和钾的浓度以及血细胞比容，并与妊娠第20天自然阴道分娩的新生小鼠进行比较。在早产小鼠中，血浆醛固酮浓度增加了两次：复苏后的出生时，以及出生后6小时。出生时的首次增加可能是由于促肾上腺皮质激素（ACTH）刺激。出生后6小时的峰值可能涉及几个因素：ACTH刺激、血浆中钠水平的降低以及由于早产小鼠肾脏不成熟导致的血细胞比容增加。结果表明，肾素 - 血管紧张素 - 醛固酮系统能够在早产小鼠出生后的前6小时对刺激做出反应。在妊娠第20天自然阴道分娩的新生小鼠（对照动物）出生时发现的血浆醛固酮水平升高并非由血浆电解质、血浆容量和ACTH的变化引起；这种升高是由分娩引起的，分娩导致肾上腺释放醛固酮。
