Lewis lung carcinoma in mice as an experimental therapy model. I. The growth kinetics and the effect of tumor on host.

Some biologic characteristics of Lewis lung carcinoma (LL) which are relevant for the experimental protocols both for the single drug and combined treatment were examined. The studies included the influence of route and size of inoculum of the median survival time (MST) of tumor bearing nice, the growth kinetics of primary tumor and time of metastases appearance. In addition the effect of tumor growth on some host parameters as hematopoietic stem cells activity and on the spleen weights was tested.