Miller R R, Ayres J A, Jersey G C, McKenna M J
Fundam Appl Toxicol. 1981 May-Jun;1(3):271-7. doi: 10.1016/s0272-0590(81)80127-3.
Male and female Fischer 344 rats and B6C3F1 mice were exposed to 0, 5, 25 or 75 ppm acrylic acid vapors 6 hours per day, 5 days per week, for 13 weeks. These exposure levels were selected after conducting a 2-week probe study in which 225 ppm caused pronounced growth retardation and nasal lesions in both rats and mice. The 13-week exposures had no adverse effect on the growth of male and female rats and male mice. However, mean body weight gains of female mice in the 25 and 75 ppm exposure groups were statistically significantly lower than for controls after 12 weeks of exposure. There were no pronounced treatment related effects on organ weights, hematologic parameters, clinical chemistry parameters or urinary parameters. Histopathologic examinations revealed lesions of the nasal mucosa in rats in the 75 ppm exposure group, and in some or all mice at each treatment level. The nasal lesions were primarily localized to the olfactory epithelium; the respiratory epithelium was relatively unaffected. The histopathologic observations in both rats and mice included degeneration, and inflammatory cell infiltration in the olfactory mucosa. In mice there were also instances of hyperplasia of the submucosal glands and, replacement of olfactory epithelium by respiratory epithelium. These effects were attributed to the irritant properties of acrylic acid vapors.
将雄性和雌性费希尔344大鼠以及B6C3F1小鼠每天暴露于0、5、25或75 ppm的丙烯酸蒸气中，每天6小时，每周5天，持续13周。在进行了为期2周的探索性研究后选择了这些暴露水平，在该研究中，225 ppm导致大鼠和小鼠均出现明显的生长迟缓和鼻损伤。13周的暴露对雄性和雌性大鼠以及雄性小鼠的生长没有不利影响。然而，在暴露12周后，25 ppm和75 ppm暴露组雌性小鼠的平均体重增加在统计学上显著低于对照组。在器官重量、血液学参数、临床化学参数或尿液参数方面没有明显的与治疗相关的影响。组织病理学检查显示，75 ppm暴露组大鼠以及每个处理水平的部分或所有小鼠出现鼻黏膜损伤。鼻损伤主要局限于嗅上皮；呼吸上皮相对未受影响。大鼠和小鼠的组织病理学观察结果包括变性以及嗅黏膜中的炎性细胞浸润。在小鼠中还存在黏膜下腺增生以及呼吸上皮替代嗅上皮的情况。这些影响归因于丙烯酸蒸气的刺激性。
