Hameroff S R, Watt R C, Borel J D, Carlson G
Physiol Chem Phys. 1982;14(3):183-7.
A model system of gaseous electron mobility, excitation, and plasma activity was used to study direct effects of six gases, including four general anesthetics, in oxygen. Helium increased, and nitrogen had minimal effects on gaseous excitation. Nitrous oxide, as well as the potent anesthetics halothane, enflurane, and isoflurane, inhibited gaseous excitation, nitrous oxide having the weakest anesthetic effect. The data are compatible with the view that anesthetic inhibition is mediated by Van der Waals dipole dispersion interactions among anesthetic molecules (e.g., halogenated hydrocarbons) and electrons accelerated by the applied field. Dipole dispersion interactions may also mediate anesthetic effects on synaptic protein conformational control.
一个气态电子迁移率、激发和等离子体活性的模型系统被用于研究包括四种全身麻醉剂在内的六种气体在氧气中的直接作用。氦气增加了气态激发，而氮气对气态激发的影响最小。一氧化二氮以及强效麻醉剂氟烷、恩氟烷和异氟烷抑制气态激发，一氧化二氮的麻醉作用最弱。这些数据与以下观点一致，即麻醉抑制是由麻醉分子（如卤代烃）与外加电场加速的电子之间的范德华偶极色散相互作用介导的。偶极色散相互作用也可能介导麻醉剂对突触蛋白构象控制的影响。
