Yamada O, Kodera K, Hink R F, Yamane H
Audiology. 1978 Nov-Dec;17(6):489-99. doi: 10.3109/00206097809072609.
The cochlear initiation of the frequency-following response (FFR) was assessed by comparing the FFR thresholds to the pure-tone thresholds in four groups of patients suffering from different forms of sensorineural hearing loss. The groups consisted of patients suffering from (1) pure high-frequency hearing losses; (2) high-frequency hearing losses mixed with moderate low-frequency losses; (3) flat hearing losses, and (4)low-frequency hearing losses. Across groups, the pattern of thresholds of the FFR evoked by 500-Hz tome bursts paralleled the pattern of pure-tone thresholds only for the low frequencies- not the high frequencies. In order to clarify the interpretation of this result, a high-pass masking experiment was performed on patients with low-frequency hearing losses. High-pass masking noise did not affect the FFR thresholds to 500-Hz tone burst, but it produced a phase shift of the FFR at stronger intensity levels. The data are interpreted as strongly supporting the view that the FFR at low levels is initiated primarily by activity in the apical portion of the cochlea.
通过比较四组患有不同形式感音神经性听力损失患者的频率跟随反应（FFR）阈值与纯音阈值，评估了耳蜗对频率跟随反应的起始作用。这四组患者分别为：（1）单纯高频听力损失患者；（2）高频听力损失合并中度低频听力损失患者；（3）平坦型听力损失患者；（4）低频听力损失患者。在所有组中，500赫兹短音诱发的FFR阈值模式仅在低频而非高频方面与纯音阈值模式平行。为了阐明这一结果的解释，对低频听力损失患者进行了高通掩蔽实验。高通掩蔽噪声并未影响对500赫兹短音的FFR阈值，但在更强强度水平下会使FFR产生相移。这些数据被解释为有力支持了以下观点：低水平的FFR主要由耳蜗顶部区域的活动起始。
