Moroji T, Watanabe N, Aoki N, Itoh S
Int Pharmacopsychiatry. 1982;17(4):255-73. doi: 10.1159/000468582.
Caerulein, a decapeptide chemically related to CCK-8, was administered intramuscularly to 20 patients with chronic schizophrenia in two different doses of 0.3 and 0.6 microgram/kg. BPRS ratings were made before and 3 weeks after the injection. The neuroleptic therapy was not discontinued, but both drug and dose were not changed at least 3 weeks before the first injection and during the study period. Clinically obvious and statistically significant improvement in psychotic symptoms occurred shortly after the injection of caerulein. The greatest change occurred 1--2 weeks later. There was an evident correlation between the observed changes and the dose injected. Our findings suggest that caerulein has a long-acting, antipsychotic activity in chronic schizophrenia. Furthermore, our findings suggest the involvement of CCK-like peptides in the pathogenesis of schizophrenia.
蛙皮素是一种与八肽胆囊收缩素化学相关的十肽，以0.3和0.6微克/千克两种不同剂量对20例慢性精神分裂症患者进行肌肉注射。在注射前及注射后3周进行简明精神病评定量表（BPRS）评分。抗精神病治疗未中断，但在首次注射前至少3周及研究期间，药物及其剂量均未改变。注射蛙皮素后不久，精神病症状出现了临床上明显且具有统计学意义的改善。最大变化发生在1 - 2周后。观察到的变化与注射剂量之间存在明显相关性。我们的研究结果表明，蛙皮素在慢性精神分裂症中具有长效抗精神病活性。此外，我们的研究结果提示胆囊收缩素样肽参与了精神分裂症的发病机制。
