Maleci A, Moretto G, Fenzi F, Poppi M, Govoni E, Bragaglia M M, Rizzuto N
Riv Patol Nerv Ment. 1982 Mar-Apr;103(2):67-80.
The results of a light and electron microscopy study of seven amputation neuromas are presented. The neuromas were removed during surgery for traumatic lesions of limbs. The histological study showed a complete disappearance of the nerve architecture at the neuroma level, where the fibres are collected in small bundles, enveloped in an abnormal perineural sheath, surrounded by an overgrowing connective tissue. In two cases a partial and incomplete reinnervation of the distal stump was found. The ultrastructural study shows abnormalities of the nervous fibers, both of the axon and of the relationships between the axonal part and the Schwann cell. The results of our data in man are compared to nerve regeneration patterns recently investigated in experimental models.
本文呈现了对7例截肢性神经瘤进行光镜和电镜研究的结果。这些神经瘤是在肢体创伤性损伤手术中切除的。组织学研究显示，在神经瘤水平神经结构完全消失，此处纤维聚集成小束，被异常的神经束膜包裹，周围是过度增生的结缔组织。在2例中发现远端残端有部分且不完全的神经再支配。超微结构研究显示神经纤维存在异常，包括轴突以及轴突部分与施万细胞之间的关系。我们在人体中的数据结果与最近在实验模型中研究的神经再生模式进行了比较。
