Age-dependence of the stimulatory effect of triiodothyronine on the DNA synthesis of rat hepatocytes.

The effect of a single subcutaneous injection of triiodothyronine (T3) on DNA synthesis rate and liver growth was studied in young and old female Wistar rats. The hormonal treatment was effective in stimulating DNA synthesis, resulting in an increase of the specific liver volume as well as volume and numerical density of nuclei/100 g body wt. in young animals. In the old animals T3 injection induced a reduced and delayed synthesis of DNA, which did not affect the morphometric parameters of liver/100 g body wt.