Filczewski M, Oledzka K, Szymańska-Kosmala M
Pol J Pharmacol Pharm. 1982 Nov-Dec;34(5-6):287-94.
An antiarrhythmic agent, AB-2, given iv produced in cats and dogs a biphasic action on blood pressure: rapid and short-lasting hypertension followed by depression of blood pressure. The first phase was accompanied by a sharp rise of serum catecholamines (6-fold increase in adrenaline, and 4.5-fold increase in noradrenaline level) and of indices of left ventricular contractility. These effects were more pronounced in cats than in dogs. In cats, but not dogs, the biphasic effect was observed also after po administration. The elevated endogenous catecholamine release was not accompanied by an increase in plasma 11-hydroxycorticosteroids levels.
一种抗心律失常药物AB - 2静脉注射给药后，在猫和狗身上对血压产生双相作用：先是快速且短暂的高血压，随后是血压降低。第一阶段伴随着血清儿茶酚胺急剧升高（肾上腺素增加6倍，去甲肾上腺素水平增加4.5倍）以及左心室收缩指标升高。这些作用在猫身上比在狗身上更明显。在猫身上，口服给药后也观察到双相作用，但在狗身上未观察到。内源性儿茶酚胺释放增加并未伴随着血浆11 - 羟皮质类固醇水平升高。
