Feinberg I
J Psychiatr Res. 1982;17(4):319-34. doi: 10.1016/0022-3956(82)90038-3.
Converging evidence indicates that a profound reorganization of human brain function takes place during adolescence: the amount of deep sleep and the rate of brain metabolism fall sharply; the latency of certain event-related potentials declines; the capacity to recover function after brain injury diminishes; and adult problem-solving "power" appears. A reduction in cortical synaptic density has recently been observed and might account for all of these changes. Such synaptic "pruning" may be analogous to the programmed elimination of neural elements in very early development. A defect in this maturational process may underlie those cases of schizophrenia that emerge during adolescence.
越来越多的证据表明，人类大脑功能在青春期会发生深刻的重组：深度睡眠量和大脑代谢率急剧下降；某些事件相关电位的潜伏期缩短；脑损伤后功能恢复能力减弱；成人解决问题的“能力”出现。最近观察到皮质突触密度降低，这可能是所有这些变化的原因。这种突触“修剪”可能类似于早期发育中神经元的程序性消除。这种成熟过程中的缺陷可能是青春期出现的精神分裂症病例的基础。
