Takada K
Yakubutsu Seishin Kodo. 1982 Jul;2(1):47-55.
The discriminative stimulus effects of a low dose of sodium pentobarbital (4 mg/kg, sc) were investigated in 10 rats trained to discriminate between the drug and saline under a 2-lever choice procedure. A food pellet was delivered after every 10 depressions of the appropriate lever, which lever was appropriate being determined by whether the drug or saline was administered prior to the daily session. Discrimination of the substances was said to have been attained when more than 8 out of the 1st 10 responses were to the appropriate lever for 10 consecutive days, and 7 rats met the criterion after 43 to 96 sessions. Stimulus generalization tests revealed the stimulus properties of the drug at 4 mg/kg to be similar to those of diazepam 0.25 mg/kg, sc and ethanol 1 g/kg, ig, but not of various doses of d-amphetamine, morphine, pentazocine, chlorpromazine, and imipramine. It was thus found that the rats could discriminate a relatively low dose of pentobarbital and that its stimulus effects do not differ from those at higher doses reported by other investigators.
在10只大鼠中研究了低剂量戊巴比妥钠（4毫克/千克，皮下注射）的辨别刺激效应，这些大鼠通过双杠杆选择程序接受训练，以区分药物和生理盐水。每按压适当杠杆10次后给予一粒食物丸，适当的杠杆由每日实验前给予的是药物还是生理盐水来确定。当在前10次反应中有超过8次连续10天对适当杠杆做出反应时，就认为达到了对这些物质的辨别，7只大鼠在43至96次实验后达到了这一标准。刺激泛化测试表明，4毫克/千克剂量的该药物的刺激特性与0.25毫克/千克皮下注射的地西泮和1克/千克灌胃的乙醇相似，但与不同剂量的右旋苯丙胺、吗啡、喷他佐辛、氯丙嗪和丙咪嗪不同。因此发现，大鼠能够辨别相对低剂量的戊巴比妥钠，并且其刺激效应与其他研究者报道的高剂量时的效应没有差异。
