White B L, Catlin F I, Stenback W A, Hawkins E D, Seilheimer D K
Int J Pediatr Otorhinolaryngol. 1980 Nov;2(4):337-46. doi: 10.1016/0165-5876(80)90039-7.
Four patients with persistent recurrent upper respiratory tract infections are presented. Electron microscopic studies of respiratory mucosal biopsies from these patients reveal ultrastructural abnormalities of cilia consisting of partial to complete loss of dynein arms, radial spoke disruption, and compound cilia. The concept of immotile cilia as an important cause of recurrent infections is receiving more attention. This study stresses the need for simple, rapid screening tests for cilial activity followed by electron microscopic evaluation in selected cases.
本文报告了4例持续性复发性上呼吸道感染患者。对这些患者呼吸道黏膜活检组织进行的电子显微镜研究显示，纤毛存在超微结构异常，包括动力蛋白臂部分或完全缺失、放射辐条破坏以及复合纤毛。不动纤毛作为反复感染的一个重要原因这一概念正受到越来越多的关注。本研究强调需要进行简单、快速的纤毛活性筛查试验，然后对选定病例进行电子显微镜评估。
