Jovanovic U J, Dreyfus J F
Int Pharmacopsychiatry. 1982;17 Suppl 2:136-45.
Zopiclone, a new hypnotic with an original chemical structure, was compared in a sleep laboratory study with nitrazepam according to a double-blind, parallel group randomized design. Zopiclone (7.5 mg) and nitrazepam (5 mg) were each given for 14 nights to 5 insomniacs; a placebo washout period of 4 nights and a placebo withdrawal period of 10 nights were included in the design. Both drugs were found to be immediately and lastingly effective. Some slight insomnia rebound was found with nitrazepam, but not with zopiclone. Stage 2 was decreased, slow wave sleep (SWS) increased, and rapid eye movement unchanged by both drugs: however, only nitrazepam increased rapid eye movement latency. The differences between the effects of the drugs were quite limited. However, 3 out of 50 comparisons favoured zopiclone and none nitrazepam.
佐匹克隆是一种具有独特化学结构的新型催眠药，在一项睡眠实验室研究中，根据双盲、平行组随机设计，将其与硝西泮进行了比较。将佐匹克隆（7.5毫克）和硝西泮（5毫克）分别给予5名失眠患者，为期14个晚上；设计中包括4晚的安慰剂洗脱期和10晚的安慰剂撤药期。发现两种药物均具有即刻和持久的疗效。硝西泮出现了一些轻微的失眠反弹，但佐匹克隆没有。两种药物均使第二阶段睡眠减少，慢波睡眠（SWS）增加，快速眼动睡眠无变化：然而，只有硝西泮增加了快速眼动睡眠潜伏期。两种药物的效果差异相当有限。然而，在50次比较中有3次结果支持佐匹克隆，而没有一次支持硝西泮。
