Miller F R
Invasion Metastasis. 1981;1(4):220-6.
The frequency with which metastasis occurs for three tumor sublines derived from a single mouse mammary tumor, all of which grow preferentially in mammary fatpads (as compared to the subcutis), was determined from primary tumors growing in mammary fatpads and from primary tumors growing in the subcutis. A relatively metastatic subline was found to metastasize more readily from the mammary fatpad than from subcutaneous sites. The number of metastatic nodules found in the lungs of animals following surgical removal of primary tumors transplanted into intact mammary fatpads was significantly greater than the number of nodules in the lungs of animals following surgical removal of primary tumors transplanted subcutaneously. Two sublines, which do not readily metastasize from tumors growing subcutaneously, did not metastasize from tumors growing in mammary fatpads.
从一只小鼠乳腺肿瘤衍生出的三个肿瘤亚系，它们都优先在乳腺脂肪垫中生长（与皮下组织相比），其转移发生的频率是根据在乳腺脂肪垫中生长的原发性肿瘤以及在皮下组织中生长的原发性肿瘤来确定的。发现一个相对易转移的亚系从乳腺脂肪垫转移比从皮下部位更容易。在手术切除移植到完整乳腺脂肪垫中的原发性肿瘤后，动物肺部发现的转移结节数量显著多于手术切除皮下移植的原发性肿瘤后动物肺部的结节数量。两个从皮下生长的肿瘤不易转移的亚系，从乳腺脂肪垫中生长的肿瘤也未发生转移。
