煮沸的钩端螺旋体疫苗与甲醛化钩端螺旋体疫苗在兔、仓鼠和人类中的免疫原性。
Immunogenicity of boiled compared with formalized leptospiral vaccines in rabbits, hamsters and humans.
作者信息
Adler B, Faine S
出版信息
J Hyg (Lond). 1980 Feb;84(1):1-10. doi: 10.1017/s0022172400026450.
Abstract
Leptospires (Leptospira interrogans serovar pomona) grown in chemically defined medium were immunogenic when given intradermally in humans if the leptospires were killed with formalin but not if they were boiled. Boiled leptospires were immunogenic for rabbits and hamsters and protected hamsters from challenge infection. On the other hand, boiled leptospires of the biflexa complex, serovar patoc, did retain some immunogenicity in humans, but the antisera did not protect hamsters against challenge with serovar pomona.
摘要
在化学成分确定的培养基中培养的钩端螺旋体（问号钩端螺旋体波摩那群），如果用福尔马林杀死后皮内注射给人类，具有免疫原性，但煮沸后则不然。煮沸的钩端螺旋体对兔子和仓鼠具有免疫原性，并能保护仓鼠免受攻击感染。另一方面，双曲钩端螺旋体帕托型煮沸后的菌株在人类中确实保留了一些免疫原性，但抗血清不能保护仓鼠免受波摩那群的攻击。
相似文献
1
Immunogenicity of boiled compared with formalized leptospiral vaccines in rabbits, hamsters and humans.煮沸的钩端螺旋体疫苗与甲醛化钩端螺旋体疫苗在兔、仓鼠和人类中的免疫原性。
J Hyg (Lond). 1980 Feb;84(1):1-10. doi: 10.1017/s0022172400026450.
2
Control of immunologically crossreactive leptospiral infection by administration of lipopolysaccharides from a nonpathogenic strain of Leptospira biflexa.通过给予双曲钩端螺旋体非致病菌株的脂多糖来控制免疫交叉反应性钩端螺旋体感染。
Microbiol Immunol. 2000;44(11):887-90. doi: 10.1111/j.1348-0421.2000.tb02579.x.
3
[Immunogenicity and protective capacity of leptospiral whole-cell monovalent serogroup Ballum vaccines in hamsters].[钩端螺旋体全细胞单价巴伦群疫苗在仓鼠中的免疫原性和保护能力]
Rev Argent Microbiol. 2005 Oct-Dec;37(4):169-75.
4
Antigens recognized by the human immune response to vaccination with a bivalent hardjo/pomona leptospiral vaccine.
FEMS Microbiol Immunol. 1990 Sep;2(2):111-8. doi: 10.1111/j.1574-6968.1990.tb03508.x.
5
The antibodies involved in the human immune response to leptospiral infection.参与人类对钩端螺旋体感染免疫反应的抗体。
J Med Microbiol. 1978 Nov;11(4):387-400. doi: 10.1099/00222615-11-4-387.
6
Effect of heat or formalin treatment of leptospires on antibody response detected by immunoblotting.钩端螺旋体经加热或福尔马林处理对免疫印迹法检测抗体反应的影响。
J Clin Microbiol. 1991 Jul;29(7):1548-50. doi: 10.1128/jcm.29.7.1548-1550.1991.
7
Serological and protective-antibody responses of rabbits to leptospiral antigens.
J Med Microbiol. 1978 Nov;11(4):401-9. doi: 10.1099/00222615-11-4-401.
8
ANTIGENICITY AND IMMUNOGENICITY OF LEPTOSPIRES GROWN IN CHEMICALLY CHARACTERIZED MEDIUM.在化学特性明确的培养基中培养的钩端螺旋体的抗原性和免疫原性。
Am J Vet Res. 1964 Jul;25:1277-80.
9
Indirect hemagglutination test for detection of leptospiral antibodies.用于检测钩端螺旋体抗体的间接血凝试验。
Jpn J Exp Med. 1974 Apr;44(2):191-7.
10
Chimeric epitope vaccine against Leptospira interrogans infection and induced specific immunity in guinea pigs.针对问号钩端螺旋体感染的嵌合表位疫苗及其在豚鼠中诱导的特异性免疫。
BMC Microbiol. 2016 Oct 14;16(1):241. doi: 10.1186/s12866-016-0852-y.
引用本文的文献
1
Heterologous DNA prime-protein boost immunization with RecA and FliD offers cross-clade protection against leptospiral infection.以 RecA 和 FliD 为抗原的异源 DNA 初免-蛋白加强免疫可提供针对钩端螺旋体感染的跨血清型保护。
Sci Rep. 2018 Apr 24;8(1):6447. doi: 10.1038/s41598-018-24674-8.
2
Cross-protective immunity against leptospirosis elicited by a live, attenuated lipopolysaccharide mutant.脂多糖突变弱毒活疫苗诱导的钩端螺旋体病交叉保护免疫。
J Infect Dis. 2011 Mar 15;203(6):870-9. doi: 10.1093/infdis/jiq127. Epub 2011 Jan 10.
3
Leptospirosis vaccines.钩端螺旋体病疫苗。
Microb Cell Fact. 2007 Dec 11;6:39. doi: 10.1186/1475-2859-6-39.
4
The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis.钩端螺旋体免疫球蛋白样蛋白LigA的末端部分赋予了对钩端螺旋体病仓鼠模型致死性感染的保护性免疫。
Vaccine. 2007 Aug 14;25(33):6277-86. doi: 10.1016/j.vaccine.2007.05.053. Epub 2007 Jun 14.
本文引用的文献
1
[Vaccination of humans against Weil's disease].[人类针对韦尔氏病的疫苗接种]
Nord Hyg Tidskr. 1953;5-6:109-19.
2
Growth of pathogenic Leptospira in chemically defined media.致病性钩端螺旋体在化学成分明确的培养基中的生长
J Bacteriol. 1967 May;93(5):1598-606. doi: 10.1128/jb.93.5.1598-1606.1967.
3
Antileptospiral agglutinins produced in rabbits.兔子体内产生的抗钩端螺旋体凝集素。
Bull World Health Organ. 1970;43(4):579-87.
4
5
Leptospirosis. II. Serology.钩端螺旋体病。二、血清学
Trans R Soc Trop Med Hyg. 1968;62(6):880-99. doi: 10.1016/0035-9203(68)90017-5.
6
A new leptospiral vaccine for use in man. I. Development of a vaccine from Leptospira grown on a chemically defined medium.一种用于人类的新型钩端螺旋体疫苗。I. 从在化学成分确定的培养基上生长的钩端螺旋体制备疫苗。
J Infect Dis. 1973 Nov;128(5):642-6. doi: 10.1093/infdis/128.5.642.
7
Growth requirements of pathogenic Leptospira.致病性钩端螺旋体的生长需求。
Infect Immun. 1973 Jun;7(6):886-97. doi: 10.1128/iai.7.6.886-897.1973.
8
A new leptospiral vaccine for use in man. II. Clinical and serologic evaluation of a field trial with volunteers.一种用于人类的新型钩端螺旋体疫苗。II. 志愿者现场试验的临床和血清学评估
J Infect Dis. 1973 Nov;128(5):647-51. doi: 10.1093/infdis/128.5.647.
9
Characterization of the antibodies detected by the microscopic agglutination test for bovine leptospirosis.牛钩端螺旋体病显微镜凝集试验检测到的抗体的特性分析。
J Hyg (Lond). 1974 Dec;73(3):425-32. doi: 10.1017/s0022172400042789.
10
Chemical, serological and biological properties of a serotype-specific polysaccharide antigen in Leptospira.
Aust J Exp Biol Med Sci. 1974 Apr;52(2):311-9. doi: 10.1038/icb.1974.29.
Zotero 插件