Steiner M, Haskett R F, Osmun J N, Carroll B J
Acta Psychiatr Scand. 1980 Feb;61(2):96-102. doi: 10.1111/j.1600-0447.1980.tb00569.x.
Some previous reports have suggested that lithium treatment is of benefit to women with the premenstrual tension syndrome (PMTS). In this study 15 women carefully selected for severe PMTS were given lithium carbonate (600-900 mg/day) continuously for three menstrual cycles. Lithium did not affect physical premenstrual symptoms and was ineffective in most women against behavioral premenstrual symptoms. Despite the low dosage most women also experienced significant drug-related side effects. Although a statistically significant improvement was recorded by several symptom rating instruments, this benefit was of no practical clinical value. The three women who responded best to lithium, and who requested continued treatment beyond 3 months, met diagnostic criteria for subsyndromal affective (cyclothymic) disorder. Lithium is not recommended for the average woman with PMTS.
先前的一些报告表明，锂盐治疗对患有经前紧张综合征（PMTS）的女性有益。在本研究中，15名因严重PMTS而被精心挑选出的女性连续三个月经周期服用碳酸锂（600 - 900毫克/天）。锂盐并未影响经前身体症状，并且对大多数女性的经前行为症状无效。尽管剂量较低，但大多数女性仍出现了明显的药物相关副作用。虽然几种症状评定工具记录到有统计学意义的改善，但这种益处并无实际临床价值。对锂盐反应最佳的三名女性，她们要求在3个月后继续治疗，符合亚综合征性情感（环性心境）障碍的诊断标准。不建议普通的PMTS女性使用锂盐。
