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蛋氨酸、吡哆醇与大鼠内皮损伤

Methionine, pyridoxine and endothelial lesion in rats.

作者信息

Hladovec J

出版信息

Blood Vessels. 1980;17(2):104-9. doi: 10.1159/000158239.

DOI:10.1159/000158239
PMID:7189124
Abstract

Methionine administered orally to rats produced a prolonged dose-dependent increase in endothelemia. The increase was observed after doses exceeding 100 mg/kg and was inhibited by a simultaneous administration of pyridoxine. The effect of methionine was also inhibited by trihydroxyethylrutoside and acetylsalicyclic acid. Endothelemia was increased furthermore by oral administration of cysteine and cystine and this increase was again inhibited by pyridoxine.

摘要

给大鼠口服蛋氨酸会使内皮血症出现剂量依赖性的长期增加。在剂量超过100毫克/千克后观察到这种增加,并且同时给予吡哆醇可抑制这种增加。三羟乙基芦丁和乙酰水杨酸也可抑制蛋氨酸的作用。口服半胱氨酸和胱氨酸会进一步增加内皮血症,而这种增加同样会被吡哆醇抑制。

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