Central nervous system activity of 7-substituted 1-azaphenoxathiin analogues and their oxidation products.
作者信息
Elliott A J, Eisenstein N, Iorio L C
出版信息
J Med Chem. 1980 Mar;23(3):333-5. doi: 10.1021/jm00177a028.
PMID:7189216
Abstract
A number of 7-substituted 1-azaphenoxathiins and their sulfone oxidation products have been synthesized and screened for central nervous system activity. Some of the compounds have antidepressant activity, with the most active, 7-(trifluoromethyl)-1-azaphenoxathiin 10,10-dioxide (8), having similar potency to imipramine.
摘要
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