重症肌无力：含人类和大鼠抗原的乙酰胆碱受体抗体。

Myasthenia gravis: antibodies to acetylcholine receptor with human and rat antigens.

作者信息

Oda K, Goto I, Kuroiwa Y, Onoue K, Ito Y

出版信息

Neurology. 1980 May;30(5):543-6. doi: 10.1212/wnl.30.5.543.

DOI:10.1212/wnl.30.5.543

Abstract

Serum antibodies to acetylcholine receptors (AChR) in myasthenia gravis were surveyed by radioimmunoassay, using 125I-alpha-bungarotoxin-complexed receptors of human muscles and denervated rat muscles. Antibodies were detected more frequently with human AChR than with rat AChR. Furthermore, antibody titers to human AChR were not always parallel to titers observed in the rat receptors, indicating the heterogeneity of antibody specificities in different individuals. Correlation between antibody titers and clinical severity was better when the antibody concentration was determined with human AChR. About 90% of the myasthenic sera contained antibodies to AChR, and 40% also contained other antibodies such as thyroid autoantibodies. These findings suggest that myasthenia gravis is a multiple immunopathy.

摘要

采用放射免疫分析法，使用与125I-α-银环蛇毒素结合的人肌肉和去神经大鼠肌肉受体，对重症肌无力患者血清中抗乙酰胆碱受体（AChR）抗体进行了检测。与大鼠AChR相比，人AChR检测到抗体的频率更高。此外，针对人AChR的抗体滴度并不总是与大鼠受体中观察到的滴度平行，这表明不同个体中抗体特异性存在异质性。用人AChR测定抗体浓度时，抗体滴度与临床严重程度之间的相关性更好。约90%的重症肌无力血清含有抗AChR抗体，40%还含有其他抗体，如甲状腺自身抗体。这些发现提示重症肌无力是一种多发性免疫病。