重症肌无力患者特异性抗乙酰胆碱受体抗体模式
Patient-specific anti=acetylcholine receptor antibody patterns in myasthenia gravis.
作者信息
Savage-Marengo T, Harrison R, Lunt G G, Behan P O
出版信息
J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):316-20. doi: 10.1136/jnnp.43.4.316.
Anti-acetylcholine receptor (AChR) antibodies have been determined in the sera of ten myasthenic patients over a period of several months which in each case included a series of plasma-exchanges coupled with immunosuppressive therapy. The ratio of anti-(extra-junctional rat AChR): anti-(human AChR) antibody titres was found to vary with the patient but to be constant for a given patient over the period of study. Similar indications of a patient-specific anti-AChR antibody pattern were obtained by using junctional as well as extra-junctional rat AChR and also by precipitation of human AChR in the presence of excess antiserum. Individual anti-AChR antibody patterns may have relevance to the varying courses taken by myasthenia gravis in different patients.
在几个月的时间里，对10例重症肌无力患者的血清进行了抗乙酰胆碱受体（AChR）抗体检测，在每种情况下均包括一系列血浆置换和免疫抑制治疗。发现抗（结外大鼠AChR）：抗（人AChR）抗体滴度的比值因患者而异，但在研究期间，对于给定的患者是恒定的。通过使用结内和结外大鼠AChR以及在过量抗血清存在下沉淀人AChR，也获得了患者特异性抗AChR抗体模式的类似指征。个体抗AChR抗体模式可能与重症肌无力在不同患者中所呈现的不同病程有关。
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