Nunes M C, Sobrinho L G, Calhaz-Jorge C, Santos M A, Mauricio J C, Sousa M F
Obstet Gynecol. 1980 May;55(5):591-5.
A biographic and clinical investigation of 101 patients with hyperprolactinemia and/or galactorrhea is reported. Fifty-one patients were reared without their fathers and 18 with an alcoholic, violent one. These situations were uncommon in the control population, and the differences were statistically significant. There was a high frequency of complaints of obesity, headaches, frigidity, lightheadedness, and fullness of the abdomen, limbs, or face. There was a significant temporal correlation of external events in the natural history with onset or worsening of the symptoms. It is concluded that exposure during childhood to an environment characterized by an absent or alcoholic, violent father conditions some women to develop hyperprolactinemia and/or galactorrhea later in life as a response to specific environmental changes. These conclusions apply similarly to patients with prolactinoma, idiopathic hyperprolactinemia, and euprolactinemic galactorrhea, suggesting a close relationship among the 3 entities.
本文报道了对101例高催乳素血症和/或溢乳患者的传记式及临床调查。51例患者在成长过程中没有父亲,18例患者的父亲酗酒且有暴力倾向。这些情况在对照组人群中并不常见,差异具有统计学意义。肥胖、头痛、性冷淡、头晕以及腹部、四肢或面部胀满等症状的主诉频率较高。自然病史中的外部事件与症状的发作或加重存在显著的时间相关性。研究得出结论,童年时期暴露于父亲缺席、酗酒或暴力的环境中,会使一些女性在成年后因特定环境变化而患上高催乳素血症和/或溢乳。这些结论同样适用于催乳素瘤、特发性高催乳素血症和正常催乳素血症性溢乳患者,表明这三种病症之间存在密切关系。