血清催乳素水平与男性肥胖患者的代谢指标和紊乱呈正相关。

Serum prolactin levels were positively related to metabolic indexes and disorders in male obese patients.

机构信息

State Key Laboratory of Complex Severe and Rare Diseases, Chinese Research Center for Behavior Medicine in Growth and Development, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Department of Neurosurgery, Chinese Academy of Medical Science and Peking Union Medical College, Peking Union Medical College Hospital, 100730, Beijing, China.

出版信息

Endocrine. 2024 Jun;84(3):1097-1107. doi: 10.1007/s12020-024-03743-1. Epub 2024 Feb 24.

DOI:10.1007/s12020-024-03743-1

PMID:38396200

Abstract

PURPOSE

The role of prolactin (PRL) in glucolipid metabolism was inconsistent, and there were few studies on the metabolic role of PRL in obese patients. The study aims to explore association between PRL level and metabolic disorders in male obese patients.

METHODS

A retrospective study was conducted. Eighty-nine male patients with obesity were included, and their clinical data were recorded.

RESULTS

A total of 89 male obese patients were included in this study. Their average age was 24.5 ± 9.0 years and BMI was 42.8 ± 9.1 kg/m. The average waist circumference and body fat percentage was 129.6 ± 19.6 cm and 42.9 ± 8.0%, respectively. The median prolactin levels were 10.0 ng/ml (range: 3.93-30.1 ng/ml). 79.0% (49/62) of these patients presented with NAFLD and 77.3% (68/88) of them was dyslipidemia. Further, serum prolactin level was positively correlated with BMI (r = 0.225, P = 0.034), body fat percentage (r = 0.326, P = 0.017), ALT (r = 0.273, P = 0.011) and AST (r = 0.245, P = 0.029). Compared with low PRL group (<10 ng/ml), the incidence of morbid obesity and NAFLD was higher in high PRL group (morbid obesity: 71.1% vs 45.5%, P = 0.018 and NAFLD: 91.2% vs 64.3%, P = 0.013). In addition, the risk of NAFLD and morbid obesity in high PRL group (>10 ng/ml) was higher than low PRL group (OR:5.187, 95%CI 1.194-22.544, P = 0.028 and OR: 4.375, 95% CI 1.595-11.994, P = 0.004). The increased risk of NAFLD and morbid obesity in the high PRL group still existed after adjusting for age and Testosterone.

CONCLUSION

Serum prolactin levels were positively associated with deterioration of metabolic indexes in male obese patients, as well as NAFLD and morbid obesity.

摘要

目的

催乳素（PRL）在糖脂代谢中的作用并不一致，关于肥胖患者 PRL 的代谢作用的研究较少。本研究旨在探讨男性肥胖患者 PRL 水平与代谢紊乱之间的关系。

方法

采用回顾性研究方法，共纳入 89 例男性肥胖患者，记录其临床资料。

结果

本研究共纳入 89 例男性肥胖患者，平均年龄为 24.5±9.0 岁，BMI 为 42.8±9.1kg/m²。平均腰围和体脂百分比分别为 129.6±19.6cm 和 42.9±8.0%。催乳素中位数为 10.0ng/ml（范围：3.93-30.1ng/ml）。其中 79.0%（49/62）的患者存在非酒精性脂肪性肝病，77.3%（68/88）的患者存在血脂异常。此外，血清催乳素水平与 BMI（r=0.225，P=0.034）、体脂百分比（r=0.326，P=0.017）、ALT（r=0.273，P=0.011）和 AST（r=0.245，P=0.029）呈正相关。与低 PRL 组（<10ng/ml）相比，高 PRL 组中病态肥胖和非酒精性脂肪性肝病的发生率更高（病态肥胖：71.1% vs 45.5%，P=0.018；非酒精性脂肪性肝病：91.2% vs 64.3%，P=0.013）。此外，高 PRL 组（>10ng/ml）发生非酒精性脂肪性肝病和病态肥胖的风险高于低 PRL 组（OR：5.187，95%CI 1.194-22.544，P=0.028；OR：4.375，95%CI 1.595-11.994，P=0.004）。在调整年龄和睾酮后，高 PRL 组中 NAFLD 和病态肥胖的风险仍然增加。