生长调节素C：垂体切除动物G0/G1期阻滞细胞体内细胞周期进程的恢复
Somatomedin C: restoration in vivo of cycle traverse in G0/G1 blocked cells of hypophysectomized animals.
作者信息
Rothstein H, Van Wyk J J, Hayden J H, Gordon S R, Weinsieder A
出版信息
Science. 1980 Apr 25;208(4442):410-2. doi: 10.1126/science.7189293.
PMID:7189293
Abstract
DNA synthesis and mitosis in frog lens epithelium are abolished by hypophysectomy and restored by somatomedin C. Both growth hormone and triiodothyronine also restore lens cell proliferation in vivo but not in vitro. Somatomedin-like activity in frog serum is diminished by hypophysectomy and is restored by growth hormone and triiodothyronine.
摘要
垂体切除可消除青蛙晶状体上皮细胞中的DNA合成和有丝分裂，而生长调节素C可使其恢复。生长激素和三碘甲状腺原氨酸在体内也可恢复晶状体细胞增殖，但在体外则不能。垂体切除可降低青蛙血清中的生长调节素样活性，而生长激素和三碘甲状腺原氨酸可使其恢复。
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