Martinchik A N, Bogdanov N G
Vopr Pitan. 1980 Mar-Apr(2):54-7.
35S-thiamine absorption was studied on an isolated strip of the small intestine in experiments on male albino rats with hypovitaminosis B1 and acute alcohol poisoning. The degree of hypovitaminosis was determined by the analysis of blood transketolase. Hypovitaminosis B1 provoked increased thiamine absorption by the mucous membrane of the small intestine. Concurrently, no changes in active transport of thiamine through the wall of the small intestine were observed. Single administration of ethanol in a dose of 5 g/kg body weight into the stomach resulted in a substantial inhibition of active transport, but thiamine accumulation by the mucous membrane remained unchanged. Therefore, ethanol affecting active transport had a less effect on passive diffusion of thiamine. This process, however, depends on thiamine depot saturation in the mucous membrane tissue.
在患有维生素B1缺乏症和急性酒精中毒的雄性白化病大鼠实验中，利用一段分离出的小肠条研究了35S-硫胺素的吸收情况。通过分析血液转酮醇酶来确定维生素缺乏症的程度。维生素B1缺乏症促使小肠黏膜对硫胺素的吸收增加。同时，未观察到硫胺素通过小肠壁的主动转运有变化。向胃内单次给予5 g/kg体重剂量的乙醇会导致主动转运受到显著抑制，但黏膜对硫胺素的积累保持不变。因此，影响主动转运的乙醇对硫胺素的被动扩散影响较小。然而，这个过程取决于黏膜组织中硫胺素储存库的饱和度。
