Peters J A, Gala R R
Brain Res. 1980 Apr 14;187(2):257-69. doi: 10.1016/0006-8993(80)90202-4.
Plasma prolactin (PRL) levels were investigated in chronically catheterized control, sham-lesioned, and amygdala (AMYG)-lesioned rats under a variety of conditions. Ovariectomized (OVX) rats injected with 0.5 mg of polyestradiol phosphate (PEP) exhibited a circadian rhythm of PRL secretion characteristic of proestrus rats. Small bilateral lesions of the central AMYG area had no effect on this pattern of PRL secretion in animals bled over a 24-h period, 1 week following lesioning. A second group of rats bearing lesions or sham lesions of the corticomedial AMYG nuclei were studied at 1, 2 and 3 weeks following surgery and PEP treatment. PEP produced a significant afternoon surge of PRL in controls at weeks 1 and 2 but not week 3. Lesions of the corticomedial AMYG nuclei had no effect on basal PRL, but significantly blunted the afternoon surge occurring at weeks 1 and 2. The effect of a larger lesion encompassing a greater proportion of the corticomedial AMYG was examined in another group of rats at 6 weeks post-lesion and 2 weeeks after PEP injection. This lesion significantly decreased PRL levels compared to controls at 5 of 6 time periods examined over a 24-h period. The effect of this lesion on PRL secretion in non-estrogenized OVX rats was also examined. There was no difference in the low, non-fluctuating 24-h PRL levels of control and lesioned rats bled at 3 or 4 weeks post-lesion.
在多种条件下，对长期插管的对照大鼠、假损伤大鼠和杏仁核（AMYG）损伤大鼠的血浆催乳素（PRL）水平进行了研究。注射0.5毫克磷酸聚雌二醇（PEP）的去卵巢（OVX）大鼠表现出发情前期大鼠特有的PRL分泌昼夜节律。在损伤后1周，对中央杏仁核区域进行双侧小损伤，对在24小时内采血的动物的这种PRL分泌模式没有影响。第二组接受皮质内侧杏仁核核团损伤或假损伤的大鼠在手术和PEP治疗后的第1、2和3周进行研究。PEP在第1周和第2周使对照大鼠的PRL在下午出现显著升高，但在第3周没有。皮质内侧杏仁核核团损伤对基础PRL没有影响，但显著减弱了第1周和第2周出现的下午PRL升高。在另一组大鼠损伤后6周和PEP注射后2周，检查了一个更大的、涵盖更大比例皮质内侧杏仁核的损伤的影响。在24小时内检查的6个时间段中的5个时间段，与对照相比，这种损伤显著降低了PRL水平。还检查了这种损伤对未雌激素化的OVX大鼠PRL分泌的影响。在损伤后3或4周采血的对照大鼠和损伤大鼠的24小时低且无波动的PRL水平没有差异。
