Lisse K, Schürenkämper P, Friedrich W, Rutkowsky J
Acta Endocrinol (Copenh). 1980 Feb;93(2):216-22. doi: 10.1530/acta.0.0930216.
The diurnal change in peripheral serum concentration of androstenedione (A) and testosterone (T) and their response to dexamethasone (DXM) and hCG was measured in 6 women with unexplained hirsutism (H), and the results compared to those from 4 women with proven polycystic ovaries (PCO) and 3 women with proven adrenal hyperandrogenism (AHA). The DXM suppression study was performed on the basis of short-term tests measuring the change in the steroid levels after iv infusion of 20 mg DXM. Response to hCG was assessed by measurement of steroids in serum collected before and for 5 days after im administration of 10 000 IU hCG. The AHA group showed a greater diurnal change than the PCO and the H group. The mean post-administration levels of A and T following DXM infusion in the AHA group were relatively lower than the levels found in both the PCO group (P less than 0.05 for A, P less than 0.10 for T) and the H group (P less than 0.05 for A, P less than 0.01 for T), but were not different between the PCO and H group (P less than 0.80 for A, P less than 0.20 for T). The mean post-administration levels of these androgens following hCG injection in both the PCO group (P less than 0.02 for A, P less than 0.01 for T) and the H group (P less than 0.10 for A, P less than 0.10 for T) were relatively higher than the levels found in the AHA group. These results suggest that in most women with unexplained hirsutism normal-sized ovaries are the source of excessive androgens.
对6名不明原因多毛症（H）女性的外周血血清雄烯二酮（A）和睾酮（T）浓度的昼夜变化及其对地塞米松（DXM）和人绒毛膜促性腺激素（hCG）的反应进行了测量，并将结果与4名经证实患有多囊卵巢（PCO）的女性和3名经证实患有肾上腺雄激素过多症（AHA）的女性的结果进行了比较。DXM抑制研究基于短期试验进行，该试验测量静脉输注20mg DXM后类固醇水平的变化。通过测量肌肉注射10000IU hCG前及注射后5天血清中的类固醇来评估对hCG的反应。AHA组的昼夜变化比PCO组和H组更大。AHA组静脉输注DXM后A和T的给药后平均水平相对低于PCO组（A的P<0.05，T的P<0.10）和H组（A的P<0.05，T的P<0.01），但PCO组和H组之间无差异（A的P<0.80，T的P<0.20）。PCO组（A的P<0.02，T的P<0.01）和H组（A的P<0.10，T的P<0.10）肌肉注射hCG后这些雄激素的给药后平均水平相对高于AHA组。这些结果表明，在大多数不明原因多毛症女性中，正常大小的卵巢是雄激素过多的来源。
