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DNA and its precursors might interact with the food preservatives, sodium sulphite and sodium benzoate.

作者信息

Njagi G D, Gopalan H N

出版信息

Experientia. 1980 Apr 15;36(4):413-4. doi: 10.1007/BF01975120.

DOI:10.1007/BF01975120
PMID:7189717
Abstract

The interaction of sodium sulphite and sodium benzoate with nucleosides and DNA has been studied in vitro. Reduction in UV-absorbance was consistently noticed. However, no new products result from such interaction. It is likely that our previous observations of the effects of the 2 food preservatives on DNA synthesis and mitotis in Vicia faba root meristems is not due to direct action of the chemicals at the level of genetic material.

摘要

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本文引用的文献

1
The effects of aqueous salt solutions on the activity coefficients of purine and pyrimidine bases and their relation to the denaturation of deoxyribonucleic acid by salts.盐水溶液对嘌呤和嘧啶碱基活度系数的影响及其与盐引起的脱氧核糖核酸变性的关系。
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The mutagenic action of sodium bisulfite.亚硫酸氢钠的诱变作用。
Biochem Biophys Res Commun. 1970 Apr 8;39(1):156-60. doi: 10.1016/0006-291x(70)90771-0.
3
Bisulfite mutagenesis in bacteriophage T4.噬菌体T4中的亚硫酸氢盐诱变
Genetics. 1971 Aug;68(4):603-7. doi: 10.1093/genetics/68.4.603.
4
[Demonstration of the mutagenic action of sodium sulfite on yeast].[亚硫酸钠对酵母诱变作用的证明]
C R Acad Hebd Seances Acad Sci D. 1972 May 15;274(20):2798-800.
5
Inactivation of valine acceptor ativity by a C-U missense change in the anticodon of yeast valine transfer ribonucleic acid.酵母缬氨酸转移核糖核酸反密码子中的C-U错义变化导致缬氨酸受体活性失活。
J Biol Chem. 1973 Aug 10;248(15):5549-51.
6
Metabolism and elimination of sulphite by rats, mice and nonkeys.大鼠、小鼠和猕猴对亚硫酸盐的代谢与排泄。
Food Cosmet Toxicol. 1973 Apr;11(2):185-98. doi: 10.1016/s0015-6264(73)80485-7.
7
Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.用沙门氏菌/哺乳动物微粒体诱变性试验检测致癌物和诱变剂的方法。
Mutat Res. 1975 Dec;31(6):347-64. doi: 10.1016/0165-1161(75)90046-1.