Yeager A M, Zinkham W H
Johns Hopkins Med J. 1980 Jun;146(6):270-4.
The temporal patterns of varicella-associated thrombocytopenia in five children seen at the Johns Hopkins Hospital suggest the existence of at least two pathogenetic mechanisms: one "infectious," with thrombocytopenia during the period of viremia; the other "post-infectious," with thrombocytopenia continuing for weeks or months afterward. Because of the subtleties of many viral illnesses, the frequency with which an active infection produces childhood idiopathic thrombocytopenic purpura may be underestimated. Studies to evaluate this hypothesis may enhance our knowledge of etiologic factors and enable more rational therapy.
在约翰霍普金斯医院就诊的5名儿童中，水痘相关性血小板减少症的时间模式提示至少存在两种发病机制：一种是“感染性”的，在病毒血症期间出现血小板减少；另一种是“感染后”的，血小板减少在之后持续数周或数月。由于许多病毒性疾病的细微之处，活动性感染导致儿童特发性血小板减少性紫癜的频率可能被低估。评估这一假说的研究可能会增进我们对病因学因素的了解，并实现更合理的治疗。
