金刚烷胺对大鼠动情周期的影响。
Effects of amantadine on the estrous cycle in rats.
作者信息
Kun I, Feszt G, Sebestyén M
出版信息
Endocrinologie. 1980 Apr-Jun;18(2):91-3.
PMID:7189900
Abstract
Amantadine, administered in single doses of 5-25 mg/kg s.c. to normal cycling rats, induced prolonged estrus, i.e. blocking of ovulation. This result supports the inhibitory role of the dopaminergic mechanisms in the LRF secretion. In larger doses, the drug led to persistent diestrus, too, probably by blocking the dopaminergic mechanisms involved in the PIF secretion. The observed effects agree with the partial dopaminergic agonist character of amantadine.
摘要
将5 - 25毫克/千克剂量的金刚烷胺皮下注射给正常发情周期的大鼠，会诱导发情期延长，即抑制排卵。这一结果支持了多巴胺能机制在促黄体释放因子分泌中的抑制作用。大剂量时，该药物也会导致持续的间情期，可能是通过阻断参与促乳素抑制因子分泌的多巴胺能机制。观察到的这些效应与金刚烷胺的部分多巴胺能激动剂特性相符。
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