Craniofacial resection following chemotherapy.

A patient with intracranial extension of an ethmoidal carcinoma is reported. Since the tumor progressed in size despite conventional radiation and chemotherapy, the patient was treated with Cis-dichlorodiamine platinum). Significant regression in the intracranial component was noted, thus allowing complete excision of the tumor through a craniofacial approach. Preoperative chemotherapy with this agent may have a role in the management of patients with paranasal sinus carcinoma if intracranial extension is present.